Inhibition of Angiotensin-Converting Enzyme Activity by Flavonoids: Structure-Activity Relationship Studies

Inhibition of Angiotensin-Converting Enzyme Activity by Flavonoids: Structure-Activity Relationship Studies

Previous studies have demonstrated that certain flavonoids can have an inhibitory effect on angiotensin-converting enzyme (ACE) activity, which plays a key role in the regulation of arterial blood pressure. In the present study, 17 flavonoids belonging to five structural subtypes were evaluated in vitro for their ability to inhibit ACE in order to establish the structural basis of their bioacti...

Inhibition of angiotensin converting enzyme activity by five Senecio species

Hypertension is a common and often progressive disorder that poses a major risk for cardiovascular and renal disease (Chalmers, 1999; Odama & Bakris, 2000). Recent data have revealed that the global burden of hypertension is an important and increasing public health problem worldwide and that the level of awareness, treatment, and control of hypertension varies considerably among countries (Kea...

Attenuation of Focal Cerebral Ischemic Injury Following Post-Ischemic Inhibition of Angiotensin Converting Enzyme (ACE) Activity in Normotensive Rat

Background: Central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. Our previous work showed that inhibition of angiotensin converting enzyme (ACE) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (I/R) injuries. This study evaluated the impacts of post-ischemic inhibition of ACE, enalapril, on brain inf...

Angiotensin Converting Enzyme in Sarcoidosis

silica exposure and serum angiotensin converting enzyme activity

background: silicosis is known in industrial workers for centuries. till recently, the mainstay of its diagnosis and progress was clinical examination of the respiratory system, pulmonary function test and chest radiography. several biomarkers such as serum angiotensin converting enzyme (ace) activity have been examined to determine the extent of silicosis. objective: to elucidate the effect of...